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pentobarbital will decrease the level or effect of naloxegol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Use of naloxegol with solid CYP3A4 inducers just isn't suggestedContraindicated (1)pentobarbital will minimize the extent or effect of doravirine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarb